Global Protein Labeling Market Forecast 2035
According to the report, the global protein labeling market is likely to grow from USD 2.7 Billion in 2025 to USD 7.2 Billion in 2035 at a highest CAGR of 9.2% during the time period. The world protein labelling market is very dynamic and developing with the growth in proteomics studies, growing need of customized medicine and technological improvement in labeling technology.
Recently, Thermo Fisher Scientific announced the development of a new fluorescent protein labeling dye that improves the sensitivity and precision of cell-based assays in cancer research. In the same vein, Merck KGaA introduced a new series of biotinylation reagents, which make it easier to build targeted therapies, allowing specific protein detection and quantification. The increasing investments in biomedical research, as well as the increasing number of chronic diseases, are supplementary to these innovations and advance the demand of protein labeling solutions.
“Key Driver, Restraint, and Growth Opportunity Shaping the Global Protein Labeling Market
Protein labeling is in growing demand due to the growth of sophisticated imaging and high-throughput screening of biomedical research. In 2024, Bio-Rad introduced a multiplex fluorescence labeling kit which enables visualization of multiple proteins in single-cell assays, which makes the procedures more efficient and provides a shorter drug discovery process.
Protein labeling is limited by expensive and complex technical reagents and kits. By early 2025, some scientists have noted difficulties with the cost and usability of new fluorescent probes sold by Thermo Fisher, which hinders their use by smaller labs and academic institutions.
Protein labeling technologies have new possibilities due to the emergence of specific therapeutics and precision diagnostics. Merck KGaA (2024) also presented biotinylation reagents of antibody-drug conjugates in 2024 and can label proteins precisely in diagnostic tests and therapeutic applications based on personalized therapy, which is an emerging market application.
Regional Analysis of Global Protein Labeling Market
- The protein labelling market is controlled by North America as the region boasts biotechnology and pharmaceutical research ecosystem. In March 2025, Thermo Fisher Scientific added to its protein labeling reagents line in Massachusetts to aid the development of large-scale proteomics and antibody-drug conjugates. The growing investment in cancer research and individualized medicine in the U.S. will further convince more people to adopt high-level labeling methods in academic and commercial-based laboratories. North America is the best location in protein labeling technologies due to biotech innovation and huge investment in research.
- In Asia Pacific, demand is increasing through fast growth in biomedical research and new life sciences sectors in China, India and Japan. In 2024 Bio-Rad introduced multiplex protein labeling kits in Shanghai and is supporting academic and pharmaceutical R&D in China.
- The growth in Europe is stimulated by strict regulatory systems and precision medicine programmes. In 2024, Merck KGaA increased protein labeling solutions in Germany to be more advanced in development of diagnostic assays and therapeutic research.
Prominent players operating in the global protein labeling market are AAT Bioquest, Inc., Abcam plc, Agilent Technologies, Inc., AnaSpec, Inc., Bio-Rad Laboratories, Inc., Biotium Inc., Cell Signaling Technology, Inc., Creative BioMart, Cytiva (Danaher Corporation), F. Hoffmann-La Roche Ltd., GE HealthCare Technologies Inc., Geno Technology, Inc. (G-Biosciences), Jena Bioscience GmbH, LI-COR Biosciences, Merck KGaA (MilliporeSigma), New England Biolabs, Inc., PerkinElmer Inc., Promega Corporation, Rockland Immunochemicals Inc., Takara Bio Inc., Thermo Fisher Scientific Inc., Vector Laboratories, and Other Key Players.
The global protein labeling market has been segmented as follows:
Global Protein Labeling Market Analysis, by Product Type
- Reagents
- Fluorescent Dyes
- Biotin-Based Reagents
- Enzymes
- Radioisotopes
- Stable Isotopes
- Nanoparticle Labels
- Quantum Dots
- Gold Nanoparticles
- Tags & Probes
- His-tag
- FLAG-tag
- HA-tag
- Others
- Others
- Kits
- Fluorescent Labeling Kits
- Biotinylation Kits
- Enzymatic Labeling Kits
- Protein Purification Kits with Labeling Support
- Isotope Labeling Kits
- Others
Global Protein Labeling Market Analysis, by Labeling Method
- In Vitro Labeling Methods
- Site-Specific Labeling
- Chemical Crosslinking
- Amino Acid Specific Labeling
- Thiol-Specific Labeling
- Amine-Specific Labeling
- Cotranslational Labeling
- Metabolic Labeling
- SILAC (Stable Isotope Labeling with Amino Acids in Cell Culture)
- Pulse-Chase Labeling
- Nanoparticle Labeling
- Gold Nanoparticle Conjugation
- Quantum Dot Labeling
- Magnetic Nanoparticle Labeling
- Dye-Based Labeling
- Fluorescent Dye Conjugation
- Chromogenic Labeling
- Chemiluminescent Labeling
- Enzymatic Labeling
- Enzyme Conjugation
- Biotin-Avidin System
- Protein Kinase Labeling
- In Vivo Labeling Methods
- Photoreactive Labeling
- UV Crosslinking
- Photo-Crosslinking
- Photocaging
- Radioactive Labeling
- Metabolic Incorporation
- Direct Iodination
- Indirect Labeling
- Genetic Labeling
- Fluorescent Protein Fusion
- Epitope Tagging
- SNAP/CLIP Tags
- Chemical Labeling Methods
- NHS Ester Conjugation
- Maleimide Conjugation
- Click Chemistry
- Bioorthogonal Labeling
- Protein Alkylation
Global Protein Labeling Market Analysis, by Application
- Mass Spectrometry
- Protein Identification
- Quantitative Proteomics
- Post-Translational Modification Analysis
- Protein-Protein Interactions
- Structural Proteomics
- Others
- Cell-Based Assays
- Flow Cytometry
- Immunofluorescence Microscopy
- Live Cell Imaging
- Cell Sorting
- Functional Assays
- Others
- Immunological Techniques
- Western Blotting
- ELISA (Enzyme-Linked Immunosorbent Assay)
- Immunohistochemistry
- Immunocytochemistry
- Immunoprecipitation
- Others
- Protein Microarrays
- Functional Protein Arrays
- Analytical Protein Arrays
- Reverse-Phase Protein Arrays
- Tissue Microarrays
- Others
- Fluorescence Microscopy
- Confocal Microscopy
- Super-Resolution Microscopy
- Two-Photon Microscopy
- FRET (Fluorescence Resonance Energy Transfer)
- Others
- Protein Purification
- Affinity Chromatography
- Immobilized Metal Affinity Chromatography
- Size Exclusion Chromatography
- Ion Exchange Chromatography
- Others
- Drug Discovery & Development
- Target Identification
- Lead Compound Screening
- ADMET Studies
- Biomarker Discovery
- Others
Global Protein Labeling Market Analysis, by End-users
- Academic & Research Institutes
- Universities
- Research Centers
- Government Laboratories
- Non-Profit Research Organizations
- Pharmaceutical & Biotechnology Companies
- Drug Discovery Companies
- Biotech Startups
- Contract Research Organizations (CROs)
- Biopharmaceutical Companies
- Diagnostic Laboratories
- Clinical Laboratories
- Reference Laboratories
- Hospital Laboratories
- Specialty Diagnostic Centers
- Hospitals & Healthcare Facilities
- Academic Medical Centers
- Community Hospitals
- Specialty Clinics
- Point-of-Care Testing Facilities
- Contract Research Organizations (CROs)
- Preclinical CROs
- Clinical CROs
- Analytical Testing Services
- Specialty CROs
Global Protein Labeling Market Analysis, by Region
- North America
- Europe
- Asia Pacific
- Middle East
- Africa
- South America
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